Having changed, or being in the process of changing, physical sex (because it does not match desired sex) by undergoing medical treatment such as hormone replacement therapy (HRT) and optionally sex reassignment surgery (SRS), or rarely only SRS.
trans- + sexual. Introduced to English along with transsexualism by David Oliver Cauldwell in 1949, based on the German word Transsexualismus coined by Magnus Hirschfeld in 1923. Popularized in the mid 1960s, around the same time that transgender was coined; transgender had become an umbrella term and largely but not entirely displaced transsexual by the 1990s.
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