From mystic + ism, from Old French mistique, from Latin mysticus, from Ancient Greek μυστικός ("secret, mystic"), from μύστης from μῡ́ω. Confer Asturian misticismu, Catalan misticisme, French mysticisme, German Mystizismus, Italian misticismo, Portuguese misticismo, Sicilian misticisimu, Spanish misticismo.
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