Not employed or enjoyed; thrown away; employed ineffectually; wasted; squandered.
Ruined or destroyed, either physically or morally; past help or hope.
Hardened beyond sensibility or recovery; alienated; insensible.
Occupied with, or under the influence of, something, so as not to notice external things.
Origin
From Middle English loste, losede and Middle English lost, ilost, ilosed, from Old English losode and Old English losod, ġelosod, equivalent to lose + -t.
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